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One-step synthesis of a piezoelectric hybrid BNNT/BaTiO 3 composite and its application in bone tissue engineering.
- Source :
-
Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2024 Sep 30; Vol. 160, pp. 106758. Date of Electronic Publication: 2024 Sep 30. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Nanomaterials with piezoelectric properties can significantly improve the applicability of polymers used in tissue engineering applications. In this study, we report the one-step synthesis of a novel hybrid piezoelectric composite comprising barium titanates and boron nitride nanotubes. This composite is distinguished by its unique microstructures, including nanoflakes, triangular boron nitride structures, and fiber-like boron nitride nanotube configurations, which contribute to its enhanced piezoelectric properties. The composite was incorporated into a chitosan-based tissue scaffold and evaluated in vitro. Electric-responsive Human Osteoblast cells cultured on the scaffolds are exposed to low-frequency ultrasound stimulation during cell growth. The biocompatibility, cell adhesion, alkaline phosphatase activities, and mineralization of osteoblast cells on the piezo-composite scaffolds were evaluated. The results show that the hybrid piezoelectric composite significantly enhances the properties of chitosan-based scaffold.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024. Published by Elsevier Ltd.)
Details
- Language :
- English
- ISSN :
- 1878-0180
- Volume :
- 160
- Database :
- MEDLINE
- Journal :
- Journal of the mechanical behavior of biomedical materials
- Publication Type :
- Academic Journal
- Accession number :
- 39357452
- Full Text :
- https://doi.org/10.1016/j.jmbbm.2024.106758