Tumor NOS2 and COX2 Spatial Juxtaposition with CD8+ T Cells Promote Metastatic and Cancer Stem Cell Niches that Lead to Poor Outcome in ER- Breast Cancer.

Authors :: Ridnour LA
Heinz WF
Cheng RYS
Wink AL
Kedei N
Pore M
Imtiaz F
Femino EL
Gonzalez AL
Coutinho LL
Moffat RL
Butcher D
Edmondson EF
Li X
Rangel MC
Kinders RJ
Rittscher J
Lipkowitz S
Wong STC
Anderson SK
McVicar DW
Glynn SA
Billiar TR
Chang JC
Hewitt SM
Ambs S
Lockett SJ
Wink DA
Source :: Cancer research communications [Cancer Res Commun] 2024 Oct 01; Vol. 4 (10), pp. 2766-2782.
Publication Year :: 2024
Abstract: Significance: This work identifies CD8-NOS2+COX2+ and CD8-NOS2-COX2+ unique cellular neighborhoods that drive the tumor immune spatial architecture of CD8+ T cells predictive of clinical outcome and can be targeted with clinically available NOS inhibitors and NSAIDs.<br /> (©2024 The Authors; Published by the American Association for Cancer Research.)

Subjects :: Humans
Female
Stem Cell Niche
Animals
Mice
Receptors, Estrogen metabolism
Neoplasm Metastasis
Tumor Microenvironment immunology
CD8-Positive T-Lymphocytes immunology
Breast Neoplasms pathology
Breast Neoplasms immunology
Cyclooxygenase 2 metabolism
Neoplastic Stem Cells pathology
Neoplastic Stem Cells drug effects
Neoplastic Stem Cells immunology
Nitric Oxide Synthase Type II metabolism

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