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Isolation, biological activity, and synthesis of isoquinoline alkaloids.
- Source :
-
Natural product reports [Nat Prod Rep] 2024 Nov 13; Vol. 41 (11), pp. 1652-1722. Date of Electronic Publication: 2024 Nov 13. - Publication Year :
- 2024
-
Abstract
- Covering: 2019 to 2023Isoquinoline alkaloids, an important class of N -based heterocyclic compounds, have attracted considerable attention from researchers worldwide. To follow up on our prior review (covering 2014-2018) and present the progress of this class of compounds, this review summarizes and provides updated literature on novel isoquinoline alkaloids isolated during the period of 2019-2023, together with their biological activity and underlying mechanisms of action. Moreover, with the rapid development of synthetic modification strategies, the synthesis strategies of isoquinoline alkaloids have been continuously optimized, and the total synthesis of these classes of natural products is reviewed critically herein. Over 250 molecules with a broad range of bioactivities, including antitumor, antibacterial, cardioprotective, anti-inflammatory, neuroprotective and other activities, are isolated and discussed. The total synthesis of more than nine classes of isoquinoline alkaloids is presented, and thirteen compounds constitute the first total synthesis. This survey provides new indications or possibilities for the discovery of new drugs from the original naturally occurring isoquinoline alkaloids.
- Subjects :
- Molecular Structure
Humans
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemical synthesis
Anti-Bacterial Agents chemistry
Antineoplastic Agents pharmacology
Antineoplastic Agents chemical synthesis
Antineoplastic Agents chemistry
Neuroprotective Agents pharmacology
Neuroprotective Agents chemical synthesis
Neuroprotective Agents chemistry
Anti-Inflammatory Agents pharmacology
Anti-Inflammatory Agents chemical synthesis
Anti-Inflammatory Agents chemistry
Cardiotonic Agents pharmacology
Cardiotonic Agents chemical synthesis
Cardiotonic Agents chemistry
Isoquinolines chemical synthesis
Isoquinolines pharmacology
Isoquinolines chemistry
Alkaloids pharmacology
Alkaloids chemical synthesis
Alkaloids chemistry
Biological Products pharmacology
Biological Products chemical synthesis
Biological Products chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1460-4752
- Volume :
- 41
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Natural product reports
- Publication Type :
- Academic Journal
- Accession number :
- 39355982
- Full Text :
- https://doi.org/10.1039/d4np00023d