Abnormal T Cells Function Associated With Intraspinal Cold Abscess Caused by Macrolide-resistant Mycoplasma pneumoniae in a Patient With X-linked Agammaglobulinemia.

Authors :: Jin YY
Wu J
Ding F
Huang H
Xu XM
Chen QM
Yin MZ
Zhong YM
Jin YL
Source :: The Pediatric infectious disease journal [Pediatr Infect Dis J] 2024 Oct 01. Date of Electronic Publication: 2024 Oct 01.
Publication Year :: 2024
Publisher :: Ahead of Print
Abstract: Intraspinal cold abscesses caused by macrolide-resistant Mycoplasma pneumoniae in patients with X-linked agammaglobulinemia have not yet been described to our knowledge. Here we describe a patient with X-linked agammaglobulinemia who developed an intraspinal cold abscess caused by macrolide-resistant M. pneumoniae . Genetic analysis revealed a hemizygous c.1566 + 1G > C (IVS15 + 1G > C) mutation in BTK gene. The patient showed relatively naive T cells and a significant proliferative defect.<br />Competing Interests: The authors have no funding or conflicts of interest to disclose.<br /> (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)

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