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Metabolic dysfunction-associated steatotic liver disease and gallbladder polyp development: an observational study.
- Source :
-
Scientific reports [Sci Rep] 2024 Sep 28; Vol. 14 (1), pp. 22446. Date of Electronic Publication: 2024 Sep 28. - Publication Year :
- 2024
-
Abstract
- The influence of metabolic dysfunction-associated steatotic liver disease (MASLD) on gallbladder polyp development in both sexes remains elusive. Therefore, to clarify the role of MASLD in gallbladder polyp development, we investigated the longitudinal association between MASLD and gallbladder polyps. In this observational study, we included 5,527 gallbladder polyp-free patients who underwent > 2 health check-ups over > 2 years. Generalized estimation equations were used to analyze associations between MASLD and gallbladder polyp development according to repeated measures at baseline and the most recent stage. Gallbladder polyp development rates in men and women were 7.5% and 5.6% (p < 0.01), respectively. MASLD was not significantly correlated with gallbladder polyp development. Regarding the association between gallbladder polyp development (men: ≥6 mm and women: ≥5 mm) and the number of MASLD components following lifestyle habits, men and women with ≥ 4 MASLD components had odds ratios of 3.397 (95% confidence interval: 1.096-10.53) and 5.338 (1.054-27.04), respectively. Higher nonalcoholic fatty liver disease fibrosis scores were associated with significant risk of gallbladder polyp development in women (1.991, 1.047-3.785). Although MASLD influence on gallbladder polyp development differs by sex, close monitoring of patients with an increasing number of MASLD components is essential to prevent gallbladder polyp development. Specifically, men with ≥ 4 MASLD components should be monitored for gallbladder polyps measuring ≥ 6 mm.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Female
Middle Aged
Adult
Risk Factors
Gallbladder pathology
Gallbladder metabolism
Non-alcoholic Fatty Liver Disease complications
Non-alcoholic Fatty Liver Disease pathology
Non-alcoholic Fatty Liver Disease metabolism
Fatty Liver pathology
Fatty Liver complications
Fatty Liver metabolism
Aged
Polyps pathology
Gallbladder Diseases pathology
Gallbladder Diseases metabolism
Gallbladder Diseases epidemiology
Gallbladder Diseases complications
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 39341964
- Full Text :
- https://doi.org/10.1038/s41598-024-73429-1