Plant-Based Products Originating from Serbia That Affect P-glycoprotein Activity.

Our review paper evaluates the impact of plant-based products, primarily derived from plants from Serbia, on P-glycoprotein (P-gp) activity and their potential in modulating drug resistance in cancer therapy. We focus on the role and regulation of P-gp in cellular physiology and its significance in addressing multidrug resistance in cancer therapy. Additionally, we discuss the modulation of P-gp activity by 55 natural product drugs, including derivatives for some of them, based on our team's research findings since 2011. Specifically, we prospect into sesquiterpenoids from the genera Artemisia , Curcuma , Ferula , Inula , Petasites , and Celastrus ; diterpenoids from the genera Salvia and Euphorbia ; chalcones from the genera Piper , Glycyrrhiza , Cullen , Artemisia , and Humulus ; riccardins from the genera Lunularia , Monoclea , Dumortiera , Plagiochila , and Primula ; and diarylheptanoids from the genera Alnus and Curcuma . Through comprehensive analysis, we aim to highlight the potential of natural products mainly identified in plants from Serbia in influencing P-gp activity and overcoming drug resistance in cancer therapy, while also providing insights into future perspectives in this field.