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Apoptosis and platelet biogenesis: A new piece of information on a debated topic.
- Source :
-
British journal of haematology [Br J Haematol] 2024 Sep 27. Date of Electronic Publication: 2024 Sep 27. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Thrombocytopenia 4 (THC4) is an extremely rare form of inherited thrombocytopenia caused by mutations in the gene encoding cytochrome c (CYCS). The mechanism leading to reduced blood platelets remains unclear, although an unrestrained megakaryocyte apoptosis as a consequence of CYCS alterations has been proposed. The report of a TCH4 family with a novel CYCS variant unravels clues on the pathogenesis of this disorder and spotlights back on the still-discussed role of apoptosis in human platelet and megakaryocyte physiology. Commentary on: Štika et al. A novel thrombocytopenia-4-causing CYCS gene variant decreases caspase activity: Three-generation study. Br J Haematol 2024 (Online ahead of print). doi: 10.1111/bjh.19694.<br /> (© 2024 British Society for Haematology and John Wiley & Sons Ltd.)
Details
- Language :
- English
- ISSN :
- 1365-2141
- Database :
- MEDLINE
- Journal :
- British journal of haematology
- Publication Type :
- Academic Journal
- Accession number :
- 39329208
- Full Text :
- https://doi.org/10.1111/bjh.19794