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Advancements, challenges, and future perspectives in developing feline herpesvirus 1 as a vaccine vector.
- Source :
-
Frontiers in immunology [Front Immunol] 2024 Sep 12; Vol. 15, pp. 1445387. Date of Electronic Publication: 2024 Sep 12 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- As the most prevalent companion animal, cats are threatened by numerous infectious diseases and carry zoonotic pathogens such as Toxoplasma gondii and Bartonella henselae , which are the primary causes of human toxoplasmosis and cat-scratch disease. Vaccines play a crucial role in preventing and controlling the spread of diseases in both humans and animals. Currently, there are only three core vaccines available to prevent feline panleukopenia, feline herpesvirus, and feline calicivirus infections, with few vaccines available for other significant feline infectious and zoonotic diseases. Feline herpesvirus, a major component of the core vaccine, offers several advantages and a stable genetic manipulation platform, making it an ideal model for vaccine vector development to prevent and control feline infectious diseases. This paper reviews the technologies involved in the research and development of the feline herpesvirus vaccine vector, including homologous recombination, CRISPR/Cas9, and bacterial artificial chromosomes. It also examines the design and effectiveness of expressing antigens of other pathogens using the feline herpesvirus as a vaccine vector. Additionally, the paper analyzes existing technical bottlenecks and challenges, providing an outlook on its application prospects. The aim of this review is to provide a scientific basis for the research and development of feline herpesvirus as a vaccine vector and to offer new ideas for the prevention and control of significant feline infectious and zoonotic diseases.<br />Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.<br /> (Copyright © 2024 Luo, Liang, Liang, Tang, Hou, Ding, Li and Tang.)
- Subjects :
- Animals
Cats
Herpesviridae Infections prevention & control
Herpesviridae Infections veterinary
Herpesviridae Infections immunology
Herpesviridae Infections virology
Viral Vaccines immunology
Vaccine Development
Humans
CRISPR-Cas Systems
Varicellovirus
Genetic Vectors
Cat Diseases prevention & control
Cat Diseases immunology
Cat Diseases virology
Subjects
Details
- Language :
- English
- ISSN :
- 1664-3224
- Volume :
- 15
- Database :
- MEDLINE
- Journal :
- Frontiers in immunology
- Publication Type :
- Academic Journal
- Accession number :
- 39328406
- Full Text :
- https://doi.org/10.3389/fimmu.2024.1445387