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A prospective study to compare the diagnostic accuracy of 99m Tc-CNDG SPECT/CT and contrast-enhanced CT in staging of non-small cell lung cancer.
- Source :
-
Journal of cancer research and clinical oncology [J Cancer Res Clin Oncol] 2024 Sep 26; Vol. 150 (9), pp. 430. Date of Electronic Publication: 2024 Sep 26. - Publication Year :
- 2024
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Abstract
- Objective: To explore the value of <superscript>99m</superscript> Tc-isonitrile deoxyglucosamine (CNDG) SPECT/CT in the staging and resectability diagnosis of non-small cell lung cancer (NSCLC) compared with contrast-enhanced CT (CECT).<br />Methods: This research was approved by the hospital ethics review committee. Sixty-three patients with NSCLC received <superscript>99m</superscript> Tc-CNDG SPECT/CT, CECT and initial TNM staging before treatment. Thirty-three patients who underwent radical surgery underwent postoperative pathological TNM staging as the reference standard. Another thirty patients underwent radiochemotherapy; among them, the reference standard of 7 patients of N staging and 5 patients of M staging was based on biopsy pathology, and the diagnosis of the remaining lesions was confirmed by at least one different image or clinical imaging follow-up for more than 3 months. The McNemar test and receiver operating characteristic (ROC) curve analysis were used to compare the diagnostic accuracy of staging and resectability of <superscript>99m</superscript> Tc-CNDG SPECT/CT and CECT in NSCLC, respectively.<br />Results: For all patients and surgical patients, the accuracies of <superscript>99m</superscript> Tc-CNDG SPECT/CT in diagnosing the T stage and N stage were higher than those of CECT (all patients: 90.5%, 88.9% vs. 79.4%, 60.3%; surgical patients: 81.8%, 78.8% vs. 60.6%, 51.5%), and the differences were statistically significant (all patients: T stage, P = 0.016; N stage, P = 0.000; surgical patients: T stage, P = 0.016; N stage, P = 0.004). For all patients, the accuracy of <superscript>99m</superscript> Tc-CNDG SPECT/CT in diagnosing the M stage was higher than that of CECT (96.8% vs. 90.5%), but the difference was not statistically significant (P = 0.289). ROC curve analysis showed that the accuracy of <superscript>99m</superscript> Tc-CNDG SPECT/CT in diagnosing the potential resectability of NSCLC was significantly better than that of CECT (P = 0.046).<br />Conclusion: This preliminary clinical study shows that <superscript>99m</superscript> Tc-CNDG SPECT/CT is of great value for accurate clinical staging of NSCLC compared with CECT and can significantly improve the accuracy of resectability diagnosis.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Male
Female
Middle Aged
Prospective Studies
Aged
Adult
Radiopharmaceuticals
Contrast Media
Single Photon Emission Computed Tomography Computed Tomography methods
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung diagnostic imaging
Carcinoma, Non-Small-Cell Lung pathology
Lung Neoplasms pathology
Lung Neoplasms diagnostic imaging
Lung Neoplasms surgery
Neoplasm Staging methods
Tomography, X-Ray Computed methods
Subjects
Details
- Language :
- English
- ISSN :
- 1432-1335
- Volume :
- 150
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of cancer research and clinical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 39327339
- Full Text :
- https://doi.org/10.1007/s00432-024-05953-6