Intracellular C1q - an unexpected player in neuronal proteostasis.

Extrahepatic, cell-autonomous, and/or intracellularly active complement components are increasingly recognized as key orchestrators of cell physiological processes. A recent study by Scott-Hewitt et al. demonstrates that microglia-derived C1q unexpectedly associates with the ribosomes of neurons in the aging murine brain, where it impacts protein translation and impairs the extinction of conditioned fear responses.
Competing Interests: Declaration of interests The authors declare no competing interests.
(Published by Elsevier Ltd.)