Engineering biotin anchored-MWCNTs as a superb carrier for facile delivery of the potent Ru(II)-N^N scaffold in breast cancer cells.

Authors :: Babu LT
Roy N
Dasgupta T
Ghosh S
Tamizhselvi R
Paira P
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Nov 12; Vol. 60 (91), pp. 13376-13379. Date of Electronic Publication: 2024 Nov 12.
Publication Year :: 2024
Abstract: Ru(II)-complexes have been recognised as promising in treating cancer. However, targeted delivery is an important facet to augment the efficiency of drugs. Consequently, this article portrays the construction of biotinylated-MWCNTs as an SMVT-guided nano-platform for the precise delivery of our previously-developed potent Ru(II)-scaffold, making it more effective against MCF-7 cells.

Subjects :: Humans
MCF-7 Cells
Female
Cell Survival drug effects
Biotin chemistry
Breast Neoplasms drug therapy
Breast Neoplasms pathology
Ruthenium chemistry
Ruthenium pharmacology
Nanotubes, Carbon chemistry
Drug Carriers chemistry
Coordination Complexes chemistry
Coordination Complexes pharmacology
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology

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