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Cardiovascular Risk in People Living with Human Immunodeficiency (HIV) Viremia Suppression in a Young, Mid-Eastern European Population - Preliminary Study.

Authors :
Jachymek M
Wójcik Ł
Peregud-Pogorzelska M
Parczewski M
Dembowska A
Aksak-Wąs BJ
Source :
Vascular health and risk management [Vasc Health Risk Manag] 2024 Sep 21; Vol. 20, pp. 435-445. Date of Electronic Publication: 2024 Sep 21 (Print Publication: 2024).
Publication Year :
2024

Abstract

Purpose: People living with HIV are twice as likely to develop cardiovascular diseases (CVDs) and myocardial infarction related to atherosclerosis than the uninfected population. This study aimed to evaluate the prevalence of subclinical atherosclerosis in a young, mid-eastern European population of PLWH receiving ART for undetectable viremia.<br />Patients and Methods: This was a single-centre study. We included 34 patients below 50 years old, treated in Szczecin, Poland, with confirmed HIV-1 infection, treated with antiretroviral therapy (ART), and undetectable viremia. All patients underwent coronary artery computed tomography (CACT), carotid artery intima-media thickness (IMT) evaluation, and echocardiography.<br />Results: In the primary assessment, only two (5.8%) patients had an increased CVD risk calculated using the Framingham Risk Score (FRS), but we identified coronary or carotid plaques in 26.5% of the patients. Neither traditional risk factors nor those associated with HIV significantly influenced the presence of the plaque. IMT was significantly positively correlated with age and the FRS (R=0.38, p=0.04). Relative wall thickness assessed in echocardiography was higher in those with plaque (0.49 vs 0.44, p=0.04) and significantly correlated with IMT (R=0.38, p=0.04).<br />Conclusion: In our population, more than a quarter of PLWH with undetectable viremia had subclinical atherosclerosis in either the coronary or carotid arteries. The FRS underpredicted atherosclerosis in this population. The role of RWT as a possible early marker of atherosclerosis needs further studies.<br />Competing Interests: The authors report no conflicts of interest in this work.<br /> (© 2024 Jachymek et al.)

Details

Language :
English
ISSN :
1178-2048
Volume :
20
Database :
MEDLINE
Journal :
Vascular health and risk management
Publication Type :
Academic Journal
Accession number :
39324108
Full Text :
https://doi.org/10.2147/VHRM.S472328