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Cardiovascular Risk in People Living with Human Immunodeficiency (HIV) Viremia Suppression in a Young, Mid-Eastern European Population - Preliminary Study.
- Source :
-
Vascular health and risk management [Vasc Health Risk Manag] 2024 Sep 21; Vol. 20, pp. 435-445. Date of Electronic Publication: 2024 Sep 21 (Print Publication: 2024). - Publication Year :
- 2024
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Abstract
- Purpose: People living with HIV are twice as likely to develop cardiovascular diseases (CVDs) and myocardial infarction related to atherosclerosis than the uninfected population. This study aimed to evaluate the prevalence of subclinical atherosclerosis in a young, mid-eastern European population of PLWH receiving ART for undetectable viremia.<br />Patients and Methods: This was a single-centre study. We included 34 patients below 50 years old, treated in Szczecin, Poland, with confirmed HIV-1 infection, treated with antiretroviral therapy (ART), and undetectable viremia. All patients underwent coronary artery computed tomography (CACT), carotid artery intima-media thickness (IMT) evaluation, and echocardiography.<br />Results: In the primary assessment, only two (5.8%) patients had an increased CVD risk calculated using the Framingham Risk Score (FRS), but we identified coronary or carotid plaques in 26.5% of the patients. Neither traditional risk factors nor those associated with HIV significantly influenced the presence of the plaque. IMT was significantly positively correlated with age and the FRS (R=0.38, p=0.04). Relative wall thickness assessed in echocardiography was higher in those with plaque (0.49 vs 0.44, p=0.04) and significantly correlated with IMT (R=0.38, p=0.04).<br />Conclusion: In our population, more than a quarter of PLWH with undetectable viremia had subclinical atherosclerosis in either the coronary or carotid arteries. The FRS underpredicted atherosclerosis in this population. The role of RWT as a possible early marker of atherosclerosis needs further studies.<br />Competing Interests: The authors report no conflicts of interest in this work.<br /> (© 2024 Jachymek et al.)
- Subjects :
- Humans
Male
Female
Middle Aged
Adult
Poland epidemiology
Prevalence
Risk Assessment
Preliminary Data
Viremia epidemiology
Viremia drug therapy
Carotid Artery Diseases epidemiology
Carotid Artery Diseases diagnostic imaging
Coronary Artery Disease epidemiology
Coronary Artery Disease diagnostic imaging
Coronary Artery Disease diagnosis
Treatment Outcome
Plaque, Atherosclerotic
Computed Tomography Angiography
Asymptomatic Diseases
Coronary Angiography
Age Factors
Sustained Virologic Response
Viral Load
Risk Factors
Cross-Sectional Studies
HIV Infections drug therapy
HIV Infections epidemiology
HIV Infections diagnosis
HIV Infections complications
Carotid Intima-Media Thickness
Heart Disease Risk Factors
Anti-HIV Agents therapeutic use
Anti-HIV Agents adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1178-2048
- Volume :
- 20
- Database :
- MEDLINE
- Journal :
- Vascular health and risk management
- Publication Type :
- Academic Journal
- Accession number :
- 39324108
- Full Text :
- https://doi.org/10.2147/VHRM.S472328