Blood-Brain Barrier Disruption and Imaging Assessment in Stroke.

Authors :: Liang Y
Jiang Y
Liu J
Li X
Cheng X
Bao L
Zhou H
Guo Z
Source :: Translational stroke research [Transl Stroke Res] 2024 Sep 25. Date of Electronic Publication: 2024 Sep 25.
Publication Year :: 2024
Publisher :: Ahead of Print
Abstract: Disruption of the blood-brain barrier (BBB) is an important pathological hallmark of ischemic stroke. Blood-brain barrier disruption (BBBD) is a consequence of ischemia and may also exacerbate damage to brain parenchyma. Therefore, maintaining BBB integrity is critical for the central nervous system (CNS) homeostasis. This review offers a concise overview of BBB structure and function, along with the mechanisms underlying its impairment following a stroke. In addition, we review the recent imaging techniques employed to study blood-brain barrier permeability (BBBP) in the context of ischemic brain injury with the goal of providing imaging guidance for stroke diagnosis and treatment from the perspective of the BBBD. This knowledge is vital for developing strategies to safeguard the BBB during cerebral ischemia.<br /> (© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)