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Effects and mechanisms of berberine-loaded tetrahedral framework nucleic acids on osteoporosis.

Authors :
Zhang W
Guo C
Yao D
Lan W
Zhou M
Huang Z
Kong Q
Source :
Journal of materials chemistry. B [J Mater Chem B] 2024 Oct 23; Vol. 12 (41), pp. 10705-10718. Date of Electronic Publication: 2024 Oct 23.
Publication Year :
2024

Abstract

Osteoporosis is a disease that plagues the world, the complications of which, spinal fractures and hip fractures, seriously endanger the health of the elderly. At present, the main treatment for osteoporosis is anti-osteoporosis drugs, some of which, however, have poor efficacy and side effects. Thus, the development of new drugs for the treatment of osteoporosis is of clinical significance. Berberine (BBR) has a good therapeutic effect on osteoporosis, but its poor solubility and instability limit its effect. Tetrahedral framework nucleic acids (tFNAs) are a novel nano-drug delivery tool, and their good cell entry ability and stability make them an excellent carrier. Therefore, a new nanocomplex T-BBR was synthesized by carrying BBR with tFNAs. Compared with BBR, T-BBR showed better osteogenic and anti-osteoporosis abilities in both in vivo and in vitro experiments, the mechanism of which was realized through the Wnt signaling pathway.

Details

Language :
English
ISSN :
2050-7518
Volume :
12
Issue :
41
Database :
MEDLINE
Journal :
Journal of materials chemistry. B
Publication Type :
Academic Journal
Accession number :
39319556
Full Text :
https://doi.org/10.1039/d4tb01691b