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Juvenile xanthogranuloma. Clinicopathologic analysis and immunohistochemical study of 57 patients.
- Source :
-
Cancer [Cancer] 1985 Nov 01; Vol. 56 (9), pp. 2280-6. - Publication Year :
- 1985
-
Abstract
- Fifty-seven cases of juvenile xanthogranuloma that fulfilled the classic description of histologic findings of the disease were analyzed clinicopathologically and immunohistochemically. Two forms could be distinguished: 47 cases of the infantile form and 10 of the adolescent and young adult form. The infantile lesion was found at birth in 8 patients (17%), and was noted within 1 year after birth in 33 (70%). Twenty-two had multiple lesions and five of the six for whom follow-up was feasible had spontaneous involution. About half of the lesions were located on the head and neck, 30% on the trunk, and 20% on the extremities. All six adolescents had a solitary tumor located in the head and neck region. Comparison of the latter form with reticulohistiocytoma and cutaneous fibrous histiocytoma was established from a differential point of view. Immunohistochemically, most lesions of juvenile xanthogranuloma displayed a positive reaction for lysozyme and alpha-1-antichymotrypsin and were negative for S-100 protein, thereby suggesting that the essential constituents of this lesion would derive from the mononuclear phagocyte system.
Details
- Language :
- English
- ISSN :
- 0008-543X
- Volume :
- 56
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Cancer
- Publication Type :
- Academic Journal
- Accession number :
- 3931900
- Full Text :
- https://doi.org/10.1002/1097-0142(19851101)56:9<2280::aid-cncr2820560923>3.0.co;2-l