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Seroprotection against tetanus in HIV-exposed and HIV-unexposed infants in Malawi in 2019-2020.
- Source :
-
BMJ paediatrics open [BMJ Paediatr Open] 2024 Sep 24; Vol. 8 (1). Date of Electronic Publication: 2024 Sep 24. - Publication Year :
- 2024
-
Abstract
- In Malawi, tetanus toxoid vaccination (TTV) is recommended in pregnancy, but few studies have assessed the prevalence of infant seroprotection against tetanus. Anti-TT levels from 84 6-week-old infants, born in 2019-2020 to mothers living with HIV (HEU: HIV-exposed-uninfected) infants and to HIV-negative women (HUU: HIV-unexposed-uninfected) infants were determined by ELISA assay. Although 94% of the infants (HEU=94.8%, HUU=92.3%) showed protective levels (>0.1 IU/mL), the mean titers observed (0.51 IU/mL) suggest an incomplete compliance with TT vaccination. The only factor positively correlated to anti-TT IgG levels was the duration of maternal antiretroviral therapy in HEU.<br />Competing Interests: Competing interests: None declared.<br /> (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
- Subjects :
- Humans
Malawi epidemiology
Female
Infant
Pregnancy
Pregnancy Complications, Infectious immunology
Pregnancy Complications, Infectious epidemiology
Pregnancy Complications, Infectious prevention & control
Male
Antibodies, Bacterial blood
Adult
Vaccination
Enzyme-Linked Immunosorbent Assay
Tetanus prevention & control
Tetanus immunology
HIV Infections immunology
HIV Infections epidemiology
HIV Infections drug therapy
Tetanus Toxoid immunology
Tetanus Toxoid administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 2399-9772
- Volume :
- 8
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMJ paediatrics open
- Publication Type :
- Academic Journal
- Accession number :
- 39317654
- Full Text :
- https://doi.org/10.1136/bmjpo-2024-002718