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Autoantibodies neutralizing type I IFNs underlie severe tick-borne encephalitis in ∼10% of patients.
- Source :
-
The Journal of experimental medicine [J Exp Med] 2024 Oct 07; Vol. 221 (10). Date of Electronic Publication: 2024 Sep 24. - Publication Year :
- 2024
-
Abstract
- Tick-borne encephalitis (TBE) virus (TBEV) is transmitted to humans via tick bites. Infection is benign in >90% of the cases but can cause mild (<5%), moderate (<4%), or severe (<1%) encephalitis. We show here that ∼10% of patients hospitalized for severe TBE in cohorts from Austria, Czech Republic, and France carry auto-Abs neutralizing IFN-α2, -β, and/or -ω at the onset of disease, contrasting with only ∼1% of patients with moderate and mild TBE. These auto-Abs were found in two of eight patients who died and none of 13 with silent infection. The odds ratios (OR) for severe TBE in individuals with these auto-Abs relative to those without them in the general population were 4.9 (95% CI: 1.5-15.9, P < 0.0001) for the neutralization of only 100 pg/ml IFN-α2 and/or -ω, and 20.8 (95% CI: 4.5-97.4, P < 0.0001) for the neutralization of 10 ng/ml IFN-α2 and -ω. Auto-Abs neutralizing type I IFNs accounted for ∼10% of severe TBE cases in these three European cohorts.<br /> (© 2024 Gervais et al.)
Details
- Language :
- English
- ISSN :
- 1540-9538
- Volume :
- 221
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- The Journal of experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 39316018
- Full Text :
- https://doi.org/10.1084/jem.20240637