Solitary Superficial Angiomyxoma in an Uncommon Location: A Case Report and Literature Review.

Superficial angiomyxoma (SAM) is a rare, benign, and slow-growing soft tissue tumor with a tendency for frequent local recurrence. Most SAMs are solitary and sporadic. However, multiple SAMs, particularly on the external ear or eyelids, may be the initial or only sign of the Carney complex, an autosomal dominant syndrome that impacts various organs, including the heart, breasts, and skin, and is linked to endocrine hyperactivity. To ensure an accurate diagnosis, a comprehensive patient interview, physical examination, and laboratory tests, including endocrine-specific markers and imaging studies, are essential. Due to the high risk of recurrence, especially in large, encapsulated lesions, complete surgical excision is the preferred treatment approach. We present a case of a 24-year-old female with SAM on the shoulder, review the relevant literature, and discuss the pathogenesis and appropriate management of such cases.
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