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Epidermal renewal during the treatment of atopic dermatitis lesions: A study coupling line-field confocal optical coherence tomography with artificial intelligence quantifications: LC-OCT reveals new biological markers of AD.
- Source :
-
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) [Skin Res Technol] 2024 Sep; Vol. 30 (9), pp. e13891. - Publication Year :
- 2024
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Abstract
- Objective: This study explores the application of Line-field Confocal Optical Coherence Tomography (LC-OCT) imaging coupled with artificial intelligence (AI)-based algorithms to investigate atopic dermatitis (AD), a common inflammatory dermatosis.<br />Materials and Methods: AD acute and chronic lesions (ADL) were compared to clinically healthy-looking skin (ADNL). LC-OCT was used noninvasively and in real-time to image the skin of AD patients during flare-ups and monitor remissions under topical steroid treatment for 2 weeks. Quantitative parameters were extracted from the images, including morphological and cellular-level markers of epidermal architecture. A novel cellular-level parameter, nuclei "atypia," which quantifies the orderliness of epidermal renewal, was used to highlight abnormal maturation processes.<br />Results: Compared to healthy skin, AD lesions exhibited significant increases in both epidermal and stratum corneum (SC) thickness, along with a more undulated dermo-epidermal junction (DEJ). Additionally, keratinocyte nuclei (KN) were larger, less compact, and less organized in lesional areas, as indicated by the atypia parameter. A higher degree of atypia was observed in chronic lesions compared to acute ones. Following treatment, all the parameters normalized to levels observed in healthy skin within 2 weeks, mirroring clinical improvements.<br />Conclusion: This study provides insights into the quantification of epidermal renewal using a noninvasive imaging technique, highlighting differences between ADL/ADNL and acute/chronic lesions. It also presents the AD treatment mechanism, paving the way for future investigations on AD and other skin barrier function-related conditions.<br /> (© 2024 The Author(s). Skin Research and Technology published by John Wiley & Sons Ltd.)
- Subjects :
- Humans
Female
Male
Adult
Biomarkers metabolism
Biomarkers analysis
Middle Aged
Young Adult
Algorithms
Dermatitis, Atopic diagnostic imaging
Dermatitis, Atopic drug therapy
Dermatitis, Atopic pathology
Tomography, Optical Coherence methods
Artificial Intelligence
Epidermis diagnostic imaging
Epidermis pathology
Epidermis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0846
- Volume :
- 30
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)
- Publication Type :
- Academic Journal
- Accession number :
- 39305199
- Full Text :
- https://doi.org/10.1111/srt.13891