Molecular insights into hybrid tumors: Exploring the heterogeneity in plexiform ameloblastoma.

For many years, odontogenic tumors have been known to present both clinical and histopathological challenges due to their origins in the epithelial, ectomesenchymal, and/or mesenchymal components of tooth-forming tissues. Gaining a comprehensive understanding of both common and rare odontogenic tumors is crucial for their effective study and clinical management. One particularly puzzling tumor is the "plexiform ameloblastoma," a variant of the solid multicystic ameloblastoma. This term describes a distinct pattern of epithelial proliferation within the cystic cavity. Numerous studies have emphasized the variability of the stromal component, further highlighting the enigmatic nature of ameloblastoma. The presence of unique and rare features, such as primitive, mature desmoplastic, hemangiomatous, or ghost cells within the stroma of plexiform ameloblastoma, underscores the differentiation potential of the neoplastic odontogenic epithelium and offers significant insights into the tissue reactions associated with this condition. This case review discusses four instances of plexiform ameloblastoma, illustrating various atypical stromal changes and their influence on patient prognosis. It also provides important criteria for analyzing stromal alterations related to this complex odontogenic tumor.
Competing Interests: Declaration of competing interest This is to hereby state that, the author, have no financial support for the publication or writing of this manuscript. All the authors have significantly contributed for the writing, revising and final formatting of the manuscript and the respective files attached with it. Also, the authors have no conflicts regarding the publication of this manuscript amongst themselves.
(Copyright © 2024 Elsevier Inc. All rights reserved.)