A prokaryotic Argonaute protein recruits a helicase-nuclease to degrade invading plasmids.

Authors :: Ignatov D
Shanmuganathan V
Charpentier E
Source :: Cell [Cell] 2024 Sep 19; Vol. 187 (19), pp. 5223-5225.
Publication Year :: 2024
Abstract: DdmDE is a novel plasmid defense system that was discovered in the seventh pandemic Vibrio cholerae strain of the biotype O1 EI Tor. In this issue of Cell, Yang and coworkers reveal the mechanisms underlying the assembly and activation of the DdmDE defense system.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)

Subjects :: Argonaute Proteins metabolism
Argonaute Proteins genetics
Bacterial Proteins metabolism
Bacterial Proteins genetics
DNA Helicases metabolism
DNA Helicases genetics
Plasmids metabolism
Plasmids genetics
Vibrio cholerae genetics
Vibrio cholerae metabolism
Vibrio cholerae enzymology

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