Finish the unfinished: Chd1 resolving hexasome-nucleosome complex with FACT.

In this issue of Molecular Cell, Engeholm et al. ¹ present cryo-EM structures of the chromatin remodeler Chd1 bound to a hexasome-nucleosome complex, an intermediate state during transcription either with or without FACT to restore the missing H2A-H2B dimer. These two binding modes reveal how Chd1 and FACT cooperate in nucleosome re-establishment during transcription.
Competing Interests: Declaration of interests The authors declare no competing interests.
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