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Long non-coding RNA PVT1 regulates TGF-β and promotes the proliferation, migration and invasion of hypopharyngeal carcinoma FaDu cells.
- Source :
-
World journal of surgical oncology [World J Surg Oncol] 2024 Sep 20; Vol. 22 (1), pp. 254. Date of Electronic Publication: 2024 Sep 20. - Publication Year :
- 2024
-
Abstract
- Hypopharyngeal carcinoma is one of the malignant tumors of the head and neck with a particularly poor prognosis. Recurrence and metastasis are important reasons for poor prognosis of hypopharyngeal cancer patients, and malignant proliferation, migration, and invasion of tumor cells are important factors for recurrence and metastasis of hypopharyngeal cancer. Therefore, elucidating hypopharyngeal cancer cells' proliferation, migration, and invasion mechanism is essential for improving diagnosis, treatment, and prognosis. Plasmacytoma Variant Translocation 1 (PVT1) is considered a potential diagnostic marker and therapeutic target for tumors. However, it remains unclear whether PVT1 is related to the occurrence and development of hypopharyngeal cancer and its specific mechanism. In this study, the promoting effect of PVT1 on the proliferation, migration, and invasion of hypopharyngeal carcinoma FaDu cells was verified by cell biology experiments and animal studies, and it was found that PVT1 inhibited the expression of TGF-β, suggesting that PVT1 may regulate the occurrence and development of hypopharyngeal carcinoma FaDu cells through TGF-β.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Animals
Mice
Prognosis
Transforming Growth Factor beta metabolism
Tumor Cells, Cultured
Apoptosis
Xenograft Model Antitumor Assays
Mice, Nude
Cell Line, Tumor
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell metabolism
Carcinoma, Squamous Cell genetics
Mice, Inbred BALB C
Male
Biomarkers, Tumor metabolism
Biomarkers, Tumor genetics
Hypopharyngeal Neoplasms pathology
Hypopharyngeal Neoplasms genetics
Hypopharyngeal Neoplasms metabolism
RNA, Long Noncoding genetics
Cell Proliferation
Cell Movement
Neoplasm Invasiveness
Gene Expression Regulation, Neoplastic
Subjects
Details
- Language :
- English
- ISSN :
- 1477-7819
- Volume :
- 22
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- World journal of surgical oncology
- Publication Type :
- Academic Journal
- Accession number :
- 39300515
- Full Text :
- https://doi.org/10.1186/s12957-024-03536-w