Retinal electrophysiological alterations are associated with cognition in early course psychosis.

Authors :: Molho W
Stiltner B
Raymond N
Kiely C
Trotti R
Harris C
Bannai D
Keshavan M
Silverstein S
Lizano P
Source :: Schizophrenia research [Schizophr Res] 2024 Sep 17; Vol. 274, pp. 137-141. Date of Electronic Publication: 2024 Sep 17.
Publication Year :: 2024
Publisher :: Ahead of Print
Abstract: Retinal electrophysiological alterations are implicated in psychosis, but their relationship with cognition in early course psychosis (ECP) is understudied. The Brief Assessment of Cognition (BAC) and flash electroretinography (fERG) were conducted in 24 controls (HC) and 27 ECP individuals. Partial Spearman correlations were performed between fERG and BAC. Lower Photopic-1b and Scotopic-3b amplitudes were identified in ECP vs. HCs. Correlations were significant (p<0.05) between BAC Composite score and a-wave S3a and S2a and b-wave S2b and S3b conditions. Thus, ECP was characterized by lower ERG responses, and lower rod/cone/bipolar cell responses were related to poorer cognition.<br />Competing Interests: Declaration of competing interest The authors declare that they have no competing interests that could have influenced the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)

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