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Antimicrobial Peptide Hydrogel with pH-Responsive and Controllable Drug Release Properties for the Efficient Treatment of Helicobacter pylori Infection.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Oct 02; Vol. 16 (39), pp. 51981-51993. Date of Electronic Publication: 2024 Sep 18. - Publication Year :
- 2024
-
Abstract
- Helicobacter pylori is the primary cause of gastric adenocarcinoma, which afflicts more than half of the world's population and seriously affects human health. However, achieving efficient treatment of H. pylori infection by effective drug delivery and bioavailability after oral administration remains a challenge due to the harsh microenvironment, short drug retention time, and physiological barriers in the stomach. Moreover, H. pylori has shown resistance to many clinical antibiotics. Antimicrobial peptides (AMPs) exhibit substantial therapeutic efficacy against H. pylori, while they are not likely to induce drug resistance, suggesting their potential utility for the treatment of diseases related to H. pylori . In this paper, we report the design and synthesis of an AMP (GE33) hydrogel with pH-responsive and controlled peptide release properties, in which the minimal inhibitory concentration of the AMP against H. pylori is as low as 1 μg/mL. GE33 self-assembles into a stable peptide hydrogel under neutral pH conditions but decomposes into monomers or oligomers under acidic conditions. Upon oral administration of the hydrogel, the acidic gastric environment would facilitate rapid release of active AMP molecules from the hydrogel and immediate targeting of H. pylori in the stomach wall. Additionally, the remaining peptide is protected in the hydrogel, extending its retention time in the stomach, so that persistent drug release is achieved. The controlled and sustained release manner of the active molecule GE33, which enhances drug bioavailability, along with its excellent bactericidal efficacy opens a great potential for treating H. pylori infection.
- Subjects :
- Hydrogen-Ion Concentration
Animals
Antimicrobial Peptides chemistry
Antimicrobial Peptides pharmacology
Mice
Humans
Microbial Sensitivity Tests
Delayed-Action Preparations chemistry
Delayed-Action Preparations pharmacology
Delayed-Action Preparations pharmacokinetics
Helicobacter pylori drug effects
Helicobacter Infections drug therapy
Helicobacter Infections microbiology
Hydrogels chemistry
Hydrogels pharmacology
Drug Liberation
Anti-Bacterial Agents chemistry
Anti-Bacterial Agents pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 16
- Issue :
- 39
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 39292612
- Full Text :
- https://doi.org/10.1021/acsami.4c09185