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Clinical and diagnostic features of central nervous system tuberculosis in Indian children - a descriptive study.
- Source :
-
Therapeutic advances in infectious disease [Ther Adv Infect Dis] 2024 Sep 12; Vol. 11, pp. 20499361241274251. Date of Electronic Publication: 2024 Sep 12 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Background: Children with tuberculous meningitis (TBM) present with diagnostic challenges as they often have atypical clinical features.<br />Objective: To describe the baseline characteristic features of children diagnosed with central nervous system (CNS) TB (TBM and tuberculoma).<br />Design: Retrospective descriptive study.<br />Methods: Children less than 12 years presenting with neurological signs and symptoms were assessed for a therapeutic TBM trial eligibility. The results of their clinical, laboratory, neuroimaging, cerebrospinal fluid evaluations were analysed for TBM diagnosis.<br />Results: Of 600 children evaluated, 61(10%) had CNS tuberculosis; TBM 47, tuberculoma 14. 20(33%) had definite TBM. Mean age of children with TBM was 5 ± 3.4 years. Of 47, 13(28%), 21(45%) and 13(28%) had grade I, II, and III disease respectively. Abnormalities suggestive of TBM in MRI and computed tomography brain were observed in 76% (26/34) and 77% (24/31) respectively. Abnormal cerebrospinal fluid white blood cell count, protein and glucose were observed in 56% (24/43), 49% (22/45), 47% (21/45) respectively. Among 41 patients with TBM followed up until discharge, five died.<br />Conclusion: Younger children with TBM have severe forms. Confirmatory results may not be available in all. A holistic approach to care including addressing complications of hydrocephalus and strokes is needed.<br /> (© The Author(s), 2024.)
Details
- Language :
- English
- ISSN :
- 2049-9361
- Volume :
- 11
- Database :
- MEDLINE
- Journal :
- Therapeutic advances in infectious disease
- Publication Type :
- Academic Journal
- Accession number :
- 39290458
- Full Text :
- https://doi.org/10.1177/20499361241274251