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From Inception to Malignancy: the Co-evolution of Pancreatic Cancer and Its Immunosuppressive Microenvironment.
- Source :
-
Cancer research [Cancer Res] 2024 Sep 16; Vol. 84 (18), pp. 2944-2946. - Publication Year :
- 2024
-
Abstract
- Published in Cancer Research in 2007, Clark and colleagues first introduced the concept that the immune microenvironment evolves in lockstep with the progression of pancreatic cancer. Leveraging genetically engineered mouse models of the disease that were described a few years earlier, Clark and colleagues used a combination of approaches to describe the dynamics of immune evolution in precursor lesions all the way to overt malignancy. They discovered that immunosuppression is established at the earliest stages of carcinogenesis. Here, we discuss their findings, how they led to a wealth of functional work, and how they have been expanded upon since the advent of -omics technologies. See related article by Clark and colleagues, Cancer Res 2007;67:9518-27.<br /> (©2024 American Association for Cancer Research.)
Details
- Language :
- English
- ISSN :
- 1538-7445
- Volume :
- 84
- Issue :
- 18
- Database :
- MEDLINE
- Journal :
- Cancer research
- Publication Type :
- Academic Journal
- Accession number :
- 39279377
- Full Text :
- https://doi.org/10.1158/0008-5472.CAN-24-2732