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Impact of Cryopreserved Placental Allografts on Biochemical Recurrence in Prostate Cancer.
- Source :
-
Cancers [Cancers (Basel)] 2024 Aug 26; Vol. 16 (17). Date of Electronic Publication: 2024 Aug 26. - Publication Year :
- 2024
-
Abstract
- Background: Human placental allografts are widely used to promote wound healing. Placental (or amniotic membrane/umbilical cord) allografts are placed along the neurovascular bundles during radical prostatectomy to improve continence and erectile function recovery. It is unknown whether placental allografts impact biochemical recurrence (BCR).<br />Methods: This was a single-surgeon retrospective study of 566 robotic radical prostatectomies performed from April 2015 to March 2021. The patients were divided into three groups: the negative control, Brand A, and Brand B. Brand A and Brand B were both cryopreserved amniotic membrane (CAM) allografts. A total of 324 cases were included for BCR Kaplan-Meier and risk-adjusted multivariate analyses (362 for continence analysis). In vitro analyses were performed to determine the effect of CAM allografts on prostate cancer (PCa) cell line growth.<br />Results: For propensity score-matched analysis (adjusting for pre-operative PSA, tumor stage, Gleason Grade, and margin status), (1) the allograft groups did not show differences in time to BCR vs. the negative control group ( p = 0.7), and (2) combined allograft treatment groups showed better continence recovery vs. the negative controls ( p = 0.01). In vitro, placental allografts reduced PCa cell line growth in co-culture assays.<br />Conclusions: cryopreserved AM allografts (combined or individual brands) did not show a significant effect on BCR but improved continence recovery for PCa patients.
Details
- Language :
- English
- ISSN :
- 2072-6694
- Volume :
- 16
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Cancers
- Publication Type :
- Academic Journal
- Accession number :
- 39272831
- Full Text :
- https://doi.org/10.3390/cancers16172973