Back to Search
Start Over
A truncated B-box zinc finger transcription factor confers drought sensitivity in modern cultivated tomatoes.
- Source :
-
Nature communications [Nat Commun] 2024 Sep 13; Vol. 15 (1), pp. 8013. Date of Electronic Publication: 2024 Sep 13. - Publication Year :
- 2024
-
Abstract
- Enhancing drought tolerance in crops and understanding the underlying mechanisms have been subject of intense research. The precise function and molecular mechanisms of B-box zinc finger proteins (BBX) remain elusive. Here, we report a natural allele of BBX18 (BBX18 <superscript>TT</superscript> ) that encodes a C-terminal truncated protein. While most wild tomato germplasms contain the BBX18 <superscript>CC</superscript> allele and show more drought tolerant, modern cultivated tomatoes mostly carry BBX18 <superscript>TT</superscript> allele and are more drought sensitive. Knockout of BBX18 leads to improved drought tolerance in transgenic plants of cultivated tomato. Ascorbate peroxidase 1 (APX1) is identified as a BBX18-interacting protein that acts as a positive regulator of drought resistance in tomato. Chromatin immunoprecipitation sequencing analyses reveal that BBX18 binds to a unique cis-acting element of the APX1 promoter and represses its gene expression. This study provides insights into the molecular mechanism underlying drought resistance mediated by the BBX18-APX1 module in plants.<br /> (© 2024. The Author(s).)
- Subjects :
- Promoter Regions, Genetic genetics
Ascorbate Peroxidases metabolism
Ascorbate Peroxidases genetics
Alleles
Solanum lycopersicum genetics
Solanum lycopersicum metabolism
Droughts
Plant Proteins genetics
Plant Proteins metabolism
Gene Expression Regulation, Plant
Transcription Factors metabolism
Transcription Factors genetics
Plants, Genetically Modified
Zinc Fingers genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 39271661
- Full Text :
- https://doi.org/10.1038/s41467-024-51699-7