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PAM50 breast cancer subtypes and survival of patients in rural Ethiopia without adjuvant treatment: a prospective observational study.
- Source :
-
BMC cancer [BMC Cancer] 2024 Sep 10; Vol. 24 (1), pp. 1127. Date of Electronic Publication: 2024 Sep 10. - Publication Year :
- 2024
-
Abstract
- Purpose: Survival rates of breast cancer (BC) patients are particularly low in rural regions in sub-Saharan Africa (SSA) which is due to limited access to therapy. In recent years, gene expression profiling (GEP) of BC showed a strong prognostic value in patients with local tumour surgery and (neo)adjuvant treatment. The aim of this study was to evaluate the impact of intrinsic subtypes on survival of patients in rural Ethiopia without any (neo)adjuvant therapy.<br />Methods: In total, 113 female patients from Aira Hospital with histologically proven BC and treated only with surgery were included in this study. All samples were analysed by immunohistochemistry (IHC) for estrogen receptor, progesterone receptor, HER2 and Ki67, as well as RNA-expression analysis for PAM50 subtyping.<br />Results: A positive hormone receptor status was found in 69.0% of the tumours and intrinsic subtyping demonstrated Luminal B to be the most common subtype (34.5%). Follow-up data was available for 79 of 113 patients. Two-year overall survival (OS) was 57.3% and a considerably worse OS was observed in patients with Basal-like BC compared to Luminal A BC. Moreover, advanced tumours showed an increased risk of mortality.<br />Conclusion: The OS was very low in the patient cohort that received no (neo)adjuvant treatment. Immunohistochemistry and GEP confirmed endocrine-sensitive tumours in more than half of the patients, with a large proportion of Luminal B, HER2-enriched and Basal-like tumours so that adjuvant chemotherapy should be recommended.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Female
Ethiopia epidemiology
Middle Aged
Adult
Prospective Studies
Aged
Rural Population
Receptors, Progesterone metabolism
Prognosis
Biomarkers, Tumor metabolism
Gene Expression Profiling
Immunohistochemistry
Chemotherapy, Adjuvant methods
Breast Neoplasms mortality
Breast Neoplasms pathology
Breast Neoplasms therapy
Breast Neoplasms drug therapy
Breast Neoplasms metabolism
Breast Neoplasms genetics
Receptors, Estrogen metabolism
Receptor, ErbB-2 metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 39256703
- Full Text :
- https://doi.org/10.1186/s12885-024-12867-6