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The links among age, sex, and glutathione: A cross-sectional magnetic resonance spectroscopy study.
- Source :
-
Neurobiology of aging [Neurobiol Aging] 2024 Dec; Vol. 144, pp. 19-29. Date of Electronic Publication: 2024 Aug 31. - Publication Year :
- 2024
-
Abstract
- Glutathione (GSH) is a brain marker for oxidative stress and has previously been associated with cerebral amyloid deposition and memory decline. However, to date, no study has examined the links among GSH, sex, age, amyloid, and Apolipoprotein E (APOE) genotype in a large non-clinical cohort of older adults. We performed APOE genotyping, magnetic resonance spectroscopy (MRS) as well as simultaneous positron emission tomography with the radiotracer Flutemetamol (Amyloid-PET), in a group of older adults. The final analysis set comprised 140 healthy older adults (mean age: 64.7 years) and 49 participants with mild cognitive impairment (mean age: 71.4 years). We recorded metabolites in the posterior cingulate cortex (PCC) by a GSH-edited MEGAPRESS sequence. Structural equation modeling revealed that higher GSH levels were associated with female sex, but neither APOE- epsilon 4 carrier status nor age showed significant associations with GSH. Conversely, older age and the presence of an APOE4 allele, but not sex, are linked to higher global amyloid load. Our results suggest that the PCC shows sex-specific GSH alterations in older adults.<br />Competing Interests: Declaration of Competing Interest The authors have no conflicts of interest to declare that are relevant to the content of this article.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Humans
Female
Aged
Male
Middle Aged
Cross-Sectional Studies
Cognitive Dysfunction metabolism
Cognitive Dysfunction diagnostic imaging
Cognitive Dysfunction genetics
Gyrus Cinguli metabolism
Gyrus Cinguli diagnostic imaging
Oxidative Stress
Positron-Emission Tomography
Apolipoprotein E4 genetics
Genotype
Cohort Studies
Aged, 80 and over
Apolipoproteins E genetics
Apolipoproteins E metabolism
Amyloid metabolism
Glutathione metabolism
Magnetic Resonance Spectroscopy methods
Sex Characteristics
Aging metabolism
Aging genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1558-1497
- Volume :
- 144
- Database :
- MEDLINE
- Journal :
- Neurobiology of aging
- Publication Type :
- Academic Journal
- Accession number :
- 39255570
- Full Text :
- https://doi.org/10.1016/j.neurobiolaging.2024.08.010