Secondary structure changes as the potential H 2 sensing mechanism of group D [FeFe]-hydrogenases.

Authors :: Voloshyn I
Schumann C
Cabotaje PR
Zamader A
Land H
Senger M
Source :: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2024 Sep 26; Vol. 60 (78), pp. 10914-10917. Date of Electronic Publication: 2024 Sep 26.
Publication Year :: 2024
Abstract: [FeFe]-hydrogenases function as both H <subscript>2</subscript> catalysts and sensors. While catalysis is well investigated, details regarding the H <subscript>2</subscript> sensing mechanism are limited. Here, we relate protein structure changes to H <subscript>2</subscript> sensing, similar to light-driven bio-sensors. Our results highlight how identical cofactors incorporated in alternative protein scaffolds serve different functions in nature.

Subjects :: Iron-Sulfur Proteins chemistry
Iron-Sulfur Proteins metabolism
Protein Structure, Secondary
Hydrogenase chemistry
Hydrogenase metabolism
Hydrogen chemistry
Hydrogen metabolism

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