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New insight into primary hyperparathyroidism using untargeted metabolomics.
- Source :
-
Scientific reports [Sci Rep] 2024 Sep 09; Vol. 14 (1), pp. 20987. Date of Electronic Publication: 2024 Sep 09. - Publication Year :
- 2024
-
Abstract
- Primary Hyperparathyroidism (PHPT) is characterized by excessive parathormone (PTH) secretion and disrupted calcium homeostasis. Untargeted metabolomics offers a valuable approach to understanding the complex metabolic alterations associated with different diseases, including PHPT. Plasma untargeted metabolomics was applied to investigate the metabolic profiles of PHPT patients compared to a control group. Two complementary liquid-phase separation techniques were employed to comprehensively explore the metabolic landscape in this retrospective, single-center study. The study comprised 28 female patients diagnosed following the current guidelines of PHPT diagnosis and a group of 30 healthy females as a control group. To evaluate their association with PHPT, we identified changes in plasma metabolic profiles in patients with PHPT compared to the control group. The primary outcome measure included detecting plasma metabolites and discriminating PHPT patients from controls. The study unveiled specific metabolic imbalances that may link L-amino acids with peptic ulcer disease, gamma-glutamyls with oxidative stress, and asymmetric dimethylarginine (ADMA) with cardiovascular complications. Several metabolites, such as gamma-glutamyls, caffeine, sex hormones, carnitine, sphingosine-1-phosphate (S-1-P), and steroids, were connected with reduced bone mineral density (BMD). Metabolic profiling identified distinct metabolic patterns between patients with PHPT and healthy controls. These findings provided valuable insights into the pathophysiology of PHPT.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Female
Middle Aged
Retrospective Studies
Aged
Metabolome
Arginine blood
Arginine metabolism
Arginine analogs & derivatives
Bone Density
Parathyroid Hormone blood
Parathyroid Hormone metabolism
Case-Control Studies
Adult
Amino Acids blood
Amino Acids metabolism
Sphingosine analogs & derivatives
Sphingosine blood
Sphingosine metabolism
Lysophospholipids blood
Lysophospholipids metabolism
Biomarkers blood
Hyperparathyroidism, Primary blood
Hyperparathyroidism, Primary metabolism
Metabolomics methods
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 39251672
- Full Text :
- https://doi.org/10.1038/s41598-024-71423-1