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Proton therapy for adult-type diffuse glioma: A systematic review.
- Source :
-
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2024 Dec; Vol. 204, pp. 104501. Date of Electronic Publication: 2024 Sep 07. - Publication Year :
- 2024
-
Abstract
- Background: We conducted a systematic review to evaluate outcomes and toxicities associated with proton therapy in the treatment of adult-type diffuse glioma.<br />Methods: Following PRISMA guidelines, we searched PubMed for both prospective and retrospective studies on proton therapy for adult diffuse gliomas, including IDH-mutated gliomas WHO grade 2-3 and glioblastomas. Survival and toxicity outcomes were reported separately for these glioma types.<br />Results: Twelve studies from 2013 to 2023 were selected, comprising 3 prospective and 9 retrospective studies. The analysis covered 570 patients with WHO grade 2-3 gliomas and 240 patients with glioblastoma or WHO grade 4 gliomas. Proton therapy was found to be comparable to conventional radiotherapy in terms of survival outcomes. Its main advantage is the ability to minimize radiation exposure to healthy tissues.<br />Discussion: Proton therapy offers comparable survival outcomes to conventional radiotherapy for adult diffuse gliomas and may enhance treatment tolerance, especially regarding neurocognitive function. A major limitation of this review is the predominance of retrospective studies. Future research should ensure rigorous patient selection and adhere to the latest WHO 2021 classification.<br />Competing Interests: Declaration of Competing Interest All the authors certify that they have NO affiliations with or involvement in any organization or entity with any financial or other interest.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-0461
- Volume :
- 204
- Database :
- MEDLINE
- Journal :
- Critical reviews in oncology/hematology
- Publication Type :
- Academic Journal
- Accession number :
- 39251047
- Full Text :
- https://doi.org/10.1016/j.critrevonc.2024.104501