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Proton therapy for adult-type diffuse glioma: A systematic review.

Authors :
Goliot N
Mohssine S
Stefan D
Leclerc A
Emery E
Riverain J
Missohou F
Geffrelot J
Kao W
Valable S
Balosso J
Lesueur P
Source :
Critical reviews in oncology/hematology [Crit Rev Oncol Hematol] 2024 Dec; Vol. 204, pp. 104501. Date of Electronic Publication: 2024 Sep 07.
Publication Year :
2024

Abstract

Background: We conducted a systematic review to evaluate outcomes and toxicities associated with proton therapy in the treatment of adult-type diffuse glioma.<br />Methods: Following PRISMA guidelines, we searched PubMed for both prospective and retrospective studies on proton therapy for adult diffuse gliomas, including IDH-mutated gliomas WHO grade 2-3 and glioblastomas. Survival and toxicity outcomes were reported separately for these glioma types.<br />Results: Twelve studies from 2013 to 2023 were selected, comprising 3 prospective and 9 retrospective studies. The analysis covered 570 patients with WHO grade 2-3 gliomas and 240 patients with glioblastoma or WHO grade 4 gliomas. Proton therapy was found to be comparable to conventional radiotherapy in terms of survival outcomes. Its main advantage is the ability to minimize radiation exposure to healthy tissues.<br />Discussion: Proton therapy offers comparable survival outcomes to conventional radiotherapy for adult diffuse gliomas and may enhance treatment tolerance, especially regarding neurocognitive function. A major limitation of this review is the predominance of retrospective studies. Future research should ensure rigorous patient selection and adhere to the latest WHO 2021 classification.<br />Competing Interests: Declaration of Competing Interest All the authors certify that they have NO affiliations with or involvement in any organization or entity with any financial or other interest.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1879-0461
Volume :
204
Database :
MEDLINE
Journal :
Critical reviews in oncology/hematology
Publication Type :
Academic Journal
Accession number :
39251047
Full Text :
https://doi.org/10.1016/j.critrevonc.2024.104501