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[A TRH analog (DN-1417). Effects on the levels of monoamines and the metabolites in the various brain regions in rats].
- Source :
-
Nihon yakurigaku zasshi. Folia pharmacologica Japonica [Nihon Yakurigaku Zasshi] 1985 Apr; Vol. 85 (4), pp. 209-20. - Publication Year :
- 1985
-
Abstract
- The effects of a TRH (thyrotropin-releasing hormone) analog, DN-1417 (gamma-butyrolactone-gamma-carbonyl-L-histidyl-L-prolinamide citrate), on the levels of norepinephrine (NE), dopamine (DA), serotonin (5-HT) and the metabolites in the various brain regions of rats were determined by means of high performance liquid chromatography with electrochemical detection. DN-1417 (20 mg/kg, i.p.) produced marked decreases in the levels of NE, DA and 5-HT, especially in the nucleus accumbens, striatum and hypothalamus. The maximum effect was observed at 15 min after the administration. DA metabolites, 3,4-dihydroxyphenylacetic acid and homovanillic acid, increased significantly in the nucleus accumbens, striatum and hypothalamus, whereas 3-methoxy-4-hydroxyphenylglycol and 5-hydroxyindoleacetic acid remained unchanged. 3-Methoxytyramine increased significantly in the nucleus accumbens and striatum. Two week chronic administration of DN-1417 (20 mg/kg, i.p.) increased the levels of DA and NE in the nucleus accumbens and DA in the striatum. These results suggest that DN-1417 stimulates the turnover of the cerebral monoamines, especially the release of DA from the nucleus accumbens and striatum in the mesolimbic and nigro-striatal DAergic systems.
- Subjects :
- Animals
Brain Chemistry drug effects
Corpus Striatum analysis
Dopamine analysis
Haloperidol pharmacology
Hypothalamus analysis
Male
Methamphetamine pharmacology
Norepinephrine analysis
Nucleus Accumbens analysis
Rats
Rats, Inbred Strains
Serotonin analysis
Thyrotropin-Releasing Hormone pharmacology
Biogenic Amines metabolism
Brain drug effects
Thyrotropin-Releasing Hormone analogs & derivatives
Subjects
Details
- Language :
- Japanese
- ISSN :
- 0015-5691
- Volume :
- 85
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Nihon yakurigaku zasshi. Folia pharmacologica Japonica
- Publication Type :
- Academic Journal
- Accession number :
- 3924795
- Full Text :
- https://doi.org/10.1254/fpj.85.209