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Relationship between NLR and penile squamous cell carcinoma: a systematic review and meta-analysis.
- Source :
-
BMC urology [BMC Urol] 2024 Sep 06; Vol. 24 (1), pp. 194. Date of Electronic Publication: 2024 Sep 06. - Publication Year :
- 2024
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Abstract
- Objective: We conducted this study to summarize the results of studies reporting the role of NLR (neutrophil to lymphocyte ratio) in PSCC (penile squamous cell carcinoma).<br />Methods: This meta-analysis was conducted using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) criteria. A systematic search was conducted on PubMed, Scopus, and web of science up to March 10, 2023. Fourteen studies were included in the review. The NOS (Newcastle-Ottawa Scale) was used to determine the quality of the included studies. This meta-analysis was conducted on the studies reporting the relationship between NLR and survival using HR (hazard ratio) and 95% CI (confidence interval).<br />Results: There was a significant association between NLR levels and the prognosis, nodal stage, and anatomical tumor stage of PSCC patients. In the meta-analysis of the association of NLR with survival, NLR level was significantly associated with lower cancer-specific survival (HR = 3.51, 95% CI = 2.07-5.98, p < 0.001) and lower disease-free survival (HR = 2.88, 95% CI = 1.60-5.20, p < 0.001). However, NLR was found to have no association with the stage, grade, location, and size of the tumor.<br />Conclusion: NLR has a significant diagnostic and prognostic value in PSCC.<br /> (© 2024. The Author(s).)
Details
- Language :
- English
- ISSN :
- 1471-2490
- Volume :
- 24
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- BMC urology
- Publication Type :
- Academic Journal
- Accession number :
- 39243079
- Full Text :
- https://doi.org/10.1186/s12894-024-01569-7