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Intermediate HTT CAG repeats worsen disease severity in amyotrophic lateral sclerosis.

Authors :
Grassano M
Canosa A
D'Alfonso S
Corrado L
Brodini G
Koumantakis E
Cugnasco P
Manera U
Vasta R
Palumbo F
Mazzini L
Gallone S
Moglia C
Dewan R
Chia R
Ding J
Dalgard C
Gibbs RJ
Scholz S
Calvo A
Traynor B
Chio A
Source :
Journal of neurology, neurosurgery, and psychiatry [J Neurol Neurosurg Psychiatry] 2024 Sep 06. Date of Electronic Publication: 2024 Sep 06.
Publication Year :
2024
Publisher :
Ahead of Print

Abstract

Competing Interests: Competing interests: AChio serves on scientific advisory boards for Mitsubishi Tanabe, Roche, Biogen, Denali Pharma, AC Immune, Biogen, Lilly, and Cytokinetics and has received a research grant from Biogen. BT holds the US, Canadian and European patents on the clinical testing and therapeutic intervention for the hexanucleotide repeat expansion in C9orf72. BT and SS received research support from Cerevel Therapeutics. ACalvo has received a research grant from Cytokinetics. MG has received grants from the American Academy of Neurology, the American Brain Foundation and the ALS Association.

Details

Language :
English
ISSN :
1468-330X
Database :
MEDLINE
Journal :
Journal of neurology, neurosurgery, and psychiatry
Publication Type :
Editorial & Opinion
Accession number :
39242198
Full Text :
https://doi.org/10.1136/jnnp-2024-333998