Unweaving type I interferons in age-related neuroinflammation.

Authors :: Hunt DPJ
Hofer MJ
Source :: Trends in neurosciences [Trends Neurosci] 2024 Oct; Vol. 47 (10), pp. 751-752. Date of Electronic Publication: 2024 Sep 04.
Publication Year :: 2024
Abstract: Neuroinflammation is a feature of both neurodegenerative disease and normal brain aging. The roles of type I interferon (IFN-I) in the aged brain are incompletely understood. A recent article by Roy et al. reveals pervasive IFN-I activity in normal mouse brain aging, and highlights the importance of microglial IFN-I signaling in neuroinflammation.<br />Competing Interests: Declaration of interests The authors declare no competing interests in relation to this work.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)