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Neuroimaging evidence of disturbed self-appraisal in posttraumatic stress disorder: A systematic review.
- Source :
-
Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2024 Oct; Vol. 344, pp. 111888. Date of Electronic Publication: 2024 Aug 30. - Publication Year :
- 2024
-
Abstract
- Background: The experience of self-hood in posttraumatic stress disorder (PTSD) is altered cognitively and somatically. Dysfunctional negative cognitions about the self are a central mechanism of PTSD symptomatology and treatment. However, while higher-order brain models of disturbances in self-appraisal (i.e., cognitive processes relating to evaluating the self) have been examined in other psychiatric disorders, it is unclear how normative brain function during self-appraisal is impaired in PTSD.<br />Methods: This paper presents a PRISMA systematic review of functional neuroimaging studies (n = 5), to establish a neurobiological account of how self-appraisal processes are disturbed in PTSD. The review was prospectively registered with PROSPERO (CRD42023450509).<br />Results: Self-appraisal in PTSD is linked to disrupted activity in core self-processing regions of the Default Mode Network (DMN); and regions involved in cognitive control and emotion regulation, salience and valuation.<br />Limitations: Because self-appraisal in PTSD is relatively under-studied, only a small number of studies could be included for review. Cross-study heterogeneity in analytic approaches and trauma-exposure history prohibited a quantitative meta-analysis.<br />Conclusions: This paper proposes a mechanistic account of how neural dysfunctions may manifest clinically in PTSD and inform targeted selection of appropriate treatment options. We present a research agenda for future work to advance the field.<br />Competing Interests: Declaration of competing interest There are no conflicts of interest to declare.<br /> (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Brain diagnostic imaging
Brain physiopathology
Neuroimaging methods
Default Mode Network diagnostic imaging
Default Mode Network physiopathology
Functional Neuroimaging methods
Self-Assessment
Stress Disorders, Post-Traumatic diagnostic imaging
Stress Disorders, Post-Traumatic psychology
Stress Disorders, Post-Traumatic physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7506
- Volume :
- 344
- Database :
- MEDLINE
- Journal :
- Psychiatry research. Neuroimaging
- Publication Type :
- Academic Journal
- Accession number :
- 39236486
- Full Text :
- https://doi.org/10.1016/j.pscychresns.2024.111888