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Cuproptosis-associated lncRNA impact prognosis in patients with non-small cell lung cancer co-infected with COVID-19.
- Source :
-
Journal of cellular and molecular medicine [J Cell Mol Med] 2024 Sep; Vol. 28 (17), pp. e70059. - Publication Year :
- 2024
-
Abstract
- Non-small cell lung cancer (NSCLC) patients infected with COVID-19 experience much worse prognosis. However, the specific mechanisms behind this phenomenon remain unclear. We conducted a multicentre study, collecting surgical tissue samples from a total of 36 NSCLC patients across three centres to analyse. Among the 36 lung cancer patients, 9 were infected with COVID-19. COVID-19 infection (HR = 21.62 [1.58, 296.06], p = 0.021) was an independent risk factor of progression-free survival (PFS). Analysis of RNA-seq data of these cancer tissues demonstrated significantly higher expression levels of cuproptosis-associated genes in COVID-19-infected lung cancer patients. Using Lasso regression and Cox regression analysis, we identified 12 long noncoding RNAs (lncRNA) regulating cuproptosis. A score based on these lncRNA were used to divide patients into high-risk and low-risk groups. The results showed that the high-risk group had lower overall survival and PFS compared to the low-risk group. Furthermore, Tumor Immune Dysfunction and Exclusion (TIDE) database revealed that the high-risk group benefited more from immunotherapy. Drug sensitivity analysis identified cetuximab and gefitinib as potentially effective treatments for the high-risk group. Cuproptosis plays a significant role NSCLC patients infected with COVID-19. Promisingly, cetuximab and gefitinib have shown potential effectiveness for managing these patients.<br /> (© 2024 The Author(s). Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
- Subjects :
- Humans
Male
Female
Middle Aged
Prognosis
Aged
Gene Expression Regulation, Neoplastic
Carcinoma, Non-Small-Cell Lung genetics
Carcinoma, Non-Small-Cell Lung complications
Carcinoma, Non-Small-Cell Lung virology
COVID-19 genetics
COVID-19 complications
COVID-19 virology
RNA, Long Noncoding genetics
Lung Neoplasms genetics
Lung Neoplasms virology
Lung Neoplasms complications
SARS-CoV-2 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1582-4934
- Volume :
- 28
- Issue :
- 17
- Database :
- MEDLINE
- Journal :
- Journal of cellular and molecular medicine
- Publication Type :
- Academic Journal
- Accession number :
- 39228012
- Full Text :
- https://doi.org/10.1111/jcmm.70059