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Novel Perspective on Molecular and Cellular Adaptations of the Mammary Gland-Regulating Milk Constituents and Immunity of Heat-Stressed Dairy Cows.
- Source :
-
Journal of agricultural and food chemistry [J Agric Food Chem] 2024 Sep 18; Vol. 72 (37), pp. 20286-20298. Date of Electronic Publication: 2024 Sep 03. - Publication Year :
- 2024
-
Abstract
- Climate change with increasing ambient temperatures negatively influences the biology of dairy cows and their milk production in the mammary gland (MG). This study aimed to elucidate the MG proteome, differences in milk composition, and ruminal short-chain fatty acid concentrations of dairy cows experiencing 7 days of heat stress [HS, 28 °C, temperature humidity index (THI) = 76], pair-feeding (PF), or ad libitum feeding (CON) at thermoneutrality (16 °C, THI = 60). Ruminal acetate, acetate/propionate ratio, and milk urea concentrations were greater, whereas milk protein and lactose were lower in HS than in control cows. Proteome analysis revealed an induced bacterial invasion of epithelial cells, leukocyte transendothelial migration, reduction of the pyruvate and carbon metabolism, and platelet activation in the MG of HS compared to CON or PF cows. These results highlight adaptive metabolic and immune responses to mitigate the negative effects of ambient heat in the MG.
- Subjects :
- Animals
Cattle metabolism
Cattle immunology
Female
Lactation
Heat-Shock Response
Fatty Acids, Volatile metabolism
Milk Proteins metabolism
Milk Proteins analysis
Adaptation, Physiological
Milk chemistry
Milk metabolism
Mammary Glands, Animal metabolism
Mammary Glands, Animal immunology
Hot Temperature
Subjects
Details
- Language :
- English
- ISSN :
- 1520-5118
- Volume :
- 72
- Issue :
- 37
- Database :
- MEDLINE
- Journal :
- Journal of agricultural and food chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 39226405
- Full Text :
- https://doi.org/10.1021/acs.jafc.4c03879