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GPER Stimulation Attenuates Cardiac Dysfunction in a Rat Model of Preeclampsia.
- Source :
-
Hypertension (Dallas, Tex. : 1979) [Hypertension] 2024 Nov; Vol. 81 (11), pp. e161-e172. Date of Electronic Publication: 2024 Sep 03. - Publication Year :
- 2024
-
Abstract
- Background: Preeclampsia poses a substantial clinical challenge, characterized by maternal hypertension, cardiac dysfunction, and persistent cardiovascular risks for both the mother and offspring. Despite the known roles of the estrogen receptor (GPER [G protein-coupled estrogen receptor]) in placental development, its impact on cardiovascular aspects within a preeclampsia animal model remains unexplored. We propose that G-1, a GPER agonist, could have the potential to regulate not only hypertension but also cardiac dysfunction in rats with preeclampsia.<br />Methods: To explore the influence of G-1 on preeclampsia, we used the reduced uterine perfusion pressure (RUPP) model. RUPP rats were administered either G-1 (100 µg/kg per day) or hydralazine (25 mg/kg per day). We conducted echocardiography to probe the intricate cardiac effects of G-1.<br />Results: The RUPP rat model revealed signs of hypertension and cardiac dysfunction and alterations in gene and protein expression within placental and heart tissues. G-1 treatment reduced blood pressure and reversed cardiac dysfunction in rats with preeclampsia. In contrast, administration of the vasodilator hydralazine reduced blood pressure without an improvement in cardiac function. In addition, while G-1 treatment restored the levels of sFLT-1 (soluble fms-like tyrosine kinase-1) in RUPP rats, hydralazine did not normalize this antiangiogenic factor.<br />Conclusions: The therapeutic intervention of G-1 significantly mitigated the cardiovascular dysfunction observed in the RUPP rat model of preeclampsia. This discovery underscores the broader significance of understanding GPER's role in the context of preeclampsia-related cardiovascular complications.<br />Competing Interests: None.
- Subjects :
- Animals
Female
Pregnancy
Rats
Blood Pressure drug effects
Blood Pressure physiology
Quinolines pharmacology
Receptors, Estrogen metabolism
Echocardiography
Pre-Eclampsia physiopathology
Pre-Eclampsia metabolism
Pre-Eclampsia drug therapy
Disease Models, Animal
Receptors, G-Protein-Coupled metabolism
Rats, Sprague-Dawley
Hydralazine pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4563
- Volume :
- 81
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Hypertension (Dallas, Tex. : 1979)
- Publication Type :
- Academic Journal
- Accession number :
- 39224973
- Full Text :
- https://doi.org/10.1161/HYPERTENSIONAHA.123.22303