Back to Search
Start Over
[Effectiveness of a polyvalent corpuscular Pseudomonas aeruginosa vaccine, antibiotics and their combinations in experimental chronic Pseudomonas aeruginosa infection].
[Effectiveness of a polyvalent corpuscular Pseudomonas aeruginosa vaccine, antibiotics and their combinations in experimental chronic Pseudomonas aeruginosa infection].
- Source :
-
Zhurnal mikrobiologii, epidemiologii i immunobiologii [Zh Mikrobiol Epidemiol Immunobiol] 1985 Mar (3), pp. 51-6. - Publication Year :
- 1985
-
Abstract
- The data on the development of the experimental model of P. aeruginosa chronic infection in mice, produced by their intraperitoneal inoculation with the infective agent, and on the study of the properties of this model are presented. The model has been used in the experimental study of the preventive action of P. aeruginosa polyvalent corpuscular vaccine. The comparative study, carried out with the use of the proposed model, has been made with a view to evaluating the effectiveness of different methods for the treatment of P. aeruginosa chronic septic infection by means of antibiotics (polymixin B and tobramycin), P. aeruginosa polyvalent corpuscular vaccine and their combination. The combined use of this vaccine with antibiotics (polymixin B or tobramycin) has proved to give the most pronounced curative effect with respect to P. aeruginosa chronic infection.
- Subjects :
- Animals
Antibodies, Bacterial analysis
Chronic Disease
Combined Modality Therapy
Disease Models, Animal
Drug Evaluation, Preclinical
Male
Mice
Polymyxin B therapeutic use
Pseudomonas Infections microbiology
Pseudomonas Infections mortality
Pseudomonas aeruginosa isolation & purification
Time Factors
Tobramycin therapeutic use
Anti-Bacterial Agents therapeutic use
Bacterial Vaccines therapeutic use
Pseudomonas Infections therapy
Pseudomonas aeruginosa immunology
Subjects
Details
- Language :
- Russian
- ISSN :
- 0372-9311
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Zhurnal mikrobiologii, epidemiologii i immunobiologii
- Publication Type :
- Academic Journal
- Accession number :
- 3922187