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The storage mite Tyrophagus putrescentiae induces greater lung inflammation than house dust mites in mice.
- Source :
-
Parasites, hosts and diseases [Parasites Hosts Dis] 2024 Aug; Vol. 62 (3), pp. 365-377. Date of Electronic Publication: 2024 Aug 26. - Publication Year :
- 2024
-
Abstract
- Exposure to storage mite (SM) and house dust mite (HDM) allergens is a risk factor for sensitization and asthma development; however, the related immune responses and their pathology have not been fully investigated. The HDMs Dermatophagoides farinae and Dermatophagoides pteronyssinus and SM Tyrophagus putrescentiae are potent allergens that induce asthma. Most SM-related studies have focused on the allergic reactions of individuals by measuring their immunoglobulin (Ig)E expression. Considering the limited research on this topic, the present study aims to investigate the differences in the immune responses induced by HDMs and SMs and histologically analyze lung tissues in a mouse asthma model to understand the differential effects of HDM and SM. The results revealed that all mite species induced airway inflammation. Mice challenged with T. putrescentiae had the highest airway resistance and total cell, eosinophil, and neutrophil counts in the bronchoalveolar lavage fluid (BALF). The SM-sensitized groups showed more severe lesions and mucus hypersecretions than the HDM-sensitized groups. Although the degree of HDM and SM exposure was the same, the damage to the respiratory lung tissue was more severe in SM-exposed mice, which resulted in excessive mucin secretion and increased fibrosis. Furthermore, these findings suggest that SM sensitization induces a more significant hypersensitivity response in mucosal immunity than HDM sensitization in asthma models.
- Subjects :
- Animals
Mice
Female
Pneumonia immunology
Pneumonia pathology
Bronchoalveolar Lavage Fluid immunology
Bronchoalveolar Lavage Fluid cytology
Disease Models, Animal
Mice, Inbred BALB C
Acaridae immunology
Allergens immunology
Eosinophils immunology
Eosinophils pathology
Pyroglyphidae immunology
Lung immunology
Lung pathology
Asthma immunology
Asthma pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2982-6799
- Volume :
- 62
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Parasites, hosts and diseases
- Publication Type :
- Academic Journal
- Accession number :
- 39218635
- Full Text :
- https://doi.org/10.3347/PHD.24032