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Efficient delivery of curcumin by functional solid lipid nanoparticles with promoting endosomal escape and liver targeting properties.
- Source :
-
Colloids and surfaces. B, Biointerfaces [Colloids Surf B Biointerfaces] 2024 Dec; Vol. 244, pp. 114177. Date of Electronic Publication: 2024 Aug 27. - Publication Year :
- 2024
-
Abstract
- In the realm of intracellular drug delivery, overcoming the barrier of endosomal entrapment stands as a critical factor influencing the effectiveness of nanodrug delivery systems. This study focuses on the synthesis of an acid-sensitive fatty acid derivative called imidazole-stearic acid (IM-SA). Leveraging the proton sponge effect attributed to imidazole groups, IM-SA was anticipated to play a pivotal role in facilitating endosomal escape. Integrated into the lipid core of solid lipid nanoparticles (SLNs), IM-SA was paired with hyaluronic acid (HA) coating on the surface of SLNs loading with curcumin (CUR). The presence of IM-SA and HA endowed HA-IM-SLNs@CUR with dual functionalities, enabling the promotion of endosomal escape, and specifical targeting of liver cancer. HA-IM-SLNs@CUR exhibited a particle size of ∼228 nm, with impressive encapsulation efficiencies (EE) of 87.5 % ± 2.3 % for CUR. Drugs exhibit significant pH sensitive release behavior. Cellular experiments showed that HA-IM-SLN@CUR exhibits enhanced drug delivery capability. The incorporation of IM-SA significantly improved the endosomal escape of HA-IM-SLN@CUR, facilitating accelerated intracellular drug release and increasing intracellular drug concentration, exhibiting excellent growth inhibitory effects on HepG2 cells. Animal experiments revealed a 3.4-fold increase in CUR uptake at the tumor site with HA-IM-SLNs@CUR over the free CUR, demonstrating remarkable tumor homing potential with the tumor growth inhibition rate of 97.2 %. These findings indicated the significant promise of HA-IM-SLNs@CUR in the realm of cancer drug delivery.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Humans
Animals
Hep G2 Cells
Drug Liberation
Mice
Lipids chemistry
Drug Delivery Systems
Cell Proliferation drug effects
Liver metabolism
Liver drug effects
Surface Properties
Drug Carriers chemistry
Stearic Acids chemistry
Liver Neoplasms drug therapy
Liver Neoplasms pathology
Liver Neoplasms metabolism
Cell Survival drug effects
Drug Screening Assays, Antitumor
Imidazoles chemistry
Imidazoles pharmacology
Mice, Nude
Hyaluronic Acid chemistry
Mice, Inbred BALB C
Liposomes
Curcumin pharmacology
Curcumin chemistry
Nanoparticles chemistry
Endosomes metabolism
Endosomes drug effects
Antineoplastic Agents pharmacology
Antineoplastic Agents chemistry
Antineoplastic Agents administration & dosage
Particle Size
Subjects
Details
- Language :
- English
- ISSN :
- 1873-4367
- Volume :
- 244
- Database :
- MEDLINE
- Journal :
- Colloids and surfaces. B, Biointerfaces
- Publication Type :
- Academic Journal
- Accession number :
- 39217729
- Full Text :
- https://doi.org/10.1016/j.colsurfb.2024.114177