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Recombinant gamma interferon differentially regulates class II antigen expression and biosynthesis on cultured normal human keratinocytes.
- Source :
-
Journal of interferon research [J Interferon Res] 1985 Winter; Vol. 5 (1), pp. 23-32. - Publication Year :
- 1985
-
Abstract
- Recombinant gamma interferon induces class II antigen (HLA-DR) biosynthesis and expression on normal cultured human keratinocytes. HLA-DR expression was not induced on keratinocytes by recombinant alpha or beta interferons in a similar dose range nor by Con A or PHA. HLA-DR (L243) expression, as determined by FACS analysis, was detected as early as 1-2 days after addition of r-IFN-gamma to the cultures and was maximal after 4-8 days. Keratinocytes were analyzed for expression of another class II antigen, HLA-DC (Leu-10). Little or no expression of Leu-10 (DC) was detectable on these cells although Fc receptors for the IgG1 isotype were increased. These data indicate a unique role for gamma interferon in the differential regulation of keratinocyte class II antigen biosynthesis and expression. Induction of HLA-DR on keratinocytes may be functionally important in expanding the number of antigen presenting cells in the skin for the induction of an immune response and/or targeting these keratinocytes for cytolysis.
Details
- Language :
- English
- ISSN :
- 0197-8357
- Volume :
- 5
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of interferon research
- Publication Type :
- Academic Journal
- Accession number :
- 3921630
- Full Text :
- https://doi.org/10.1089/jir.1985.5.23