Back to Search
Start Over
Whole genome sequencing reveals that five genes are related to BW trait in sheep.
- Source :
-
Animal : an international journal of animal bioscience [Animal] 2024 Sep; Vol. 18 (9), pp. 101282. Date of Electronic Publication: 2024 Aug 02. - Publication Year :
- 2024
-
Abstract
- BW is an important economic trait in sheep that influences growth and development. Currently, most studies have used a single approach to screen genes associated with BW traits in sheep. To address this limitation, we conducted a genome-wide association study (GWAS) covering four different BW periods: birth, weaning, 6 months, and 12 months. Five new candidate genes: MAP3K1, ANKRD55, ABCB1, MEF2C and TRNAW-CCA-87 were screened using a combination of GWAS and quantitative trait loci analysis in sheep. Additionally, five genes were subjected to Gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses. These genes were primarily enriched in pathways related to growth hormone and energy metabolism. The results demonstrated that the above genes potentially influenced the growth and development of sheep. The five new candidate genes are closely related to the BW trait in sheep, which will be valuable for understanding the genetic mechanisms underlying BW traits and for guiding sheep breeding.<br /> (Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1751-732X
- Volume :
- 18
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Animal : an international journal of animal bioscience
- Publication Type :
- Academic Journal
- Accession number :
- 39216157
- Full Text :
- https://doi.org/10.1016/j.animal.2024.101282