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Biodistribution of PET radiotracers in tumor-bearing TRAMP mice administered by retroorbital or jugular vein injections.
- Source :
-
Scientific reports [Sci Rep] 2024 Aug 30; Vol. 14 (1), pp. 20241. Date of Electronic Publication: 2024 Aug 30. - Publication Year :
- 2024
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Abstract
- Nuclear medicine is an important tool for use in molecular imaging of important biological processes. Methods for intravenous delivery of radiotracers remains a challenge, with tail vein injections demonstrated to be technically difficult and lacking in reproducibility. Other intravenous methods include jugular vein (JV) injection, which requires a more invasive and precise microsurgical technique. Although the retroorbital (RO) sinus drains directly into the JV, and RO injections are minimally invasive and simpler to perform, they remain underutilized, perhaps due to a lack of studies demonstrating their performance. This study provides a comprehensive comparison of dynamic tissue biodistribution of three categories of commonly utilized radiopharmaceuticals between JV and RO injection methods in prostate tumor-bearing mice using PET-CT imaging. Results show that JV and RO injections have equivalent dynamic tissue biodistributions across the three categories of radiopharmaceuticals used: (1) small molecule measuring tumor metabolism ( <superscript>18</superscript> F-flurodeoxyglucose [FDG]); (2) peptide-based probe measuring angiogenesis ( <superscript>64</superscript> Cu-NOTA-PEG <subscript>4</subscript> -cRGD <subscript>2</subscript> ); and (3) dextran-based nanocarrier ( <superscript>64</superscript> Cu-NOTA-D20). Although RO injections present with some limitations such as type of injectate and difficulty for measuring acute, dynamic pharmacokinetics, this study demonstrates that RO injections are a viable, minimally invasive or stressful, and efficient alternative intravenous delivery technique for molecular imaging.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Mice
Male
Tissue Distribution
Positron Emission Tomography Computed Tomography methods
Positron-Emission Tomography methods
Injections, Intravenous
Cell Line, Tumor
Jugular Veins diagnostic imaging
Jugular Veins metabolism
Radiopharmaceuticals pharmacokinetics
Radiopharmaceuticals administration & dosage
Prostatic Neoplasms diagnostic imaging
Prostatic Neoplasms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 39215130
- Full Text :
- https://doi.org/10.1038/s41598-024-71221-9