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Proliferation of MDSCs may indicate a lower CD4+ T cell immune response in schistosomiasis japonica.
- Source :
-
Parasite (Paris, France) [Parasite] 2024; Vol. 31, pp. 52. Date of Electronic Publication: 2024 Aug 29. - Publication Year :
- 2024
-
Abstract
- Background: Schistosoma japonicum (S. japonicum) is the main species of Schistosoma prevalent in China. Myeloid-derived suppressor cells (MDSCs) are important immunoregulatory cells and generally expand in parasite infection, but there is little research relating to MDSCs in Schistosoma infection.<br />Methods: Fifty-six S. japonicum-infected patients were included in this study. MDSCs and percentages and absolute cell numbers of lymphocyte subsets, including <superscript>CD3+</superscript> T cells, <superscript>CD4+</superscript> T cells, <superscript>CD8+</superscript> T cells, B cells and natural killer (NK) cells were detected using flow cytometry. The degree of liver fibrosis was determined using color Doppler ultrasound.<br />Results: Patients infected with S. japonicum had a much higher percentage of MDSCs among peripheral blood mononuclear cells (PBMCs) than the healthy control. Regarding subpopulations of MDSCs, the percentage of granulocytic myeloid-derived suppressor cells (G-MDSCs) was clearly increased. Correlation analysis showed that the absolute cell counts of T-cell subsets correlated negatively with the percentages of MDSCs and G-MDSCs among PBMCs. The percentage of G-MDSCs in PBMCs was also significantly higher in patients with liver fibrosis diagnosed by color doppler ultrasound (grade > 0), and the percentage of G-MDSCs in PBMCs and liver fibrosis grading based on ultrasound showed a positive correlation.<br />Conclusion: S. japonicum infection contributes to an increase in MDSCs, especially G-MDSCs, whose proliferation may inhibit the number of <superscript>CD4+</superscript> T cells in peripheral blood. Meanwhile, there is a close relationship between proliferation of G-MDSCs and liver fibrosis in S. japonicum-infected patients.<br /> (© B. Peng et al., published by EDP Sciences, 2024.)
- Subjects :
- Humans
Female
Male
Adult
Middle Aged
Animals
Schistosoma japonicum immunology
Cell Proliferation
China epidemiology
Flow Cytometry
Young Adult
Aged
Leukocytes, Mononuclear immunology
Ultrasonography, Doppler, Color
Schistosomiasis japonica immunology
Schistosomiasis japonica parasitology
Myeloid-Derived Suppressor Cells immunology
CD4-Positive T-Lymphocytes immunology
Liver Cirrhosis immunology
Liver Cirrhosis parasitology
Subjects
Details
- Language :
- English
- ISSN :
- 1776-1042
- Volume :
- 31
- Database :
- MEDLINE
- Journal :
- Parasite (Paris, France)
- Publication Type :
- Academic Journal
- Accession number :
- 39212529
- Full Text :
- https://doi.org/10.1051/parasite/2024050