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Different aspects of immunological profile in patients with Non-Alcoholic Fatty liver disease.
- Source :
-
Acta gastro-enterologica Belgica [Acta Gastroenterol Belg] 2024 Apr-Jun; Vol. 87 (2), pp. 274-281. - Publication Year :
- 2024
-
Abstract
- Background: NAFLD is thought to affect approximately one-fourth of the world's population. Therefore, we evaluated the role of serum complement and immunoglobulins in the NAFLD pathogenesis.<br />Patients and Methods: 200 participants were used in this study, divided into two groups; Group I: 100 NAFLD patients and Group II: 100 healthy volunteers. The diagnosis of NAFLD is based on non-invasive methods, following the EASL guideline 2022. IgG, IgM, IgA, C3, and C4 assays were performed on all participants.<br />Results: When the immunological profiles of patients with NAFLD and healthy controls were compared, it was found that the mean IgA in NAFLD patients was (4.20±5.07), whereas the mean IgA in healthy controls was (2.22±1.05) (P=0.000). Additionally, a significant increase in IgG was found in NAFLD patients (17.08±3.87) compared with healthy controls (11.59±3.34), with a P value of (p<0.001). complement C3 and complement C4 levels significantly increased in nonalcoholic fatty liver disease patients (1.28± 0.61 and 0.40 ± 0.19, respectively), compared to healthy controls (0.90 ±0.27 and 0.30 ±0.12, respectively), with a significant P value (p<0.001 for each).<br />Conclusions: Elevated IgA, IgG, C3 and C4 exist in patients with NAFLD and could be associated with fatty liver development and progression of hepatic fibrosis in patients with NAFLD.<br />Competing Interests: The authors declare that they have no conflict of interest<br /> (© Acta Gastro-Enterologica Belgica.)
- Subjects :
- Humans
Male
Female
Adult
Middle Aged
Case-Control Studies
Complement C3 analysis
Complement C4 analysis
Complement C4 metabolism
Immunoglobulin A blood
Immunoglobulin A immunology
Immunoglobulins blood
Immunoglobulin G blood
Immunoglobulin G immunology
Complement System Proteins immunology
Complement System Proteins analysis
Non-alcoholic Fatty Liver Disease immunology
Non-alcoholic Fatty Liver Disease blood
Subjects
Details
- Language :
- English
- ISSN :
- 1784-3227
- Volume :
- 87
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Acta gastro-enterologica Belgica
- Publication Type :
- Academic Journal
- Accession number :
- 39210759
- Full Text :
- https://doi.org/10.51821/87.2.12205